The COMBINE Trial
Background
Type 2 diabetes is more common and is diagnosed at an earlier age in South Asian adults. This is worrying because diabetes can cause heart, kidney and physical function problems.
We seek to investigate whether a specialist exercise program can improve physical function in people with type 2 diabetes and low fitness.
Study aims
The aim of this trial is to see whether combining structured exercise and a high protein, low energy diet can minimise muscle loss while attempting to reverse diabetes. We will also look at whether blood sugar control is improved over 12 weeks.
Who can take part?
People from the South Asian community
Living with type 2 diabetes
Aged between 40 – 65 years old
Body mass index (BMI) between 27 and 45
What does the trial involve?
Past studies have shown that low energy diets lead up to half of people reversing their type 2 diabetes. This means that blood sugar levels return to normal. This is called ‘diabetes remission.’ A low energy diet means eating a lot less than normal for a short period of time. Once people have lost enough weight, they can start to eat regular food again.
Structured exercise, such as walking and simple weight training activities, can also improve blood sugar levels and strengthen muscle. The effect of combining the two approaches - low energy diet and structured exercise - have not been studied together in terms of reversing diabetes or preserving muscle.
There is no control group, all eligible participants will receive the diet intervention.
Study summary
Study progress
Recruiting
Funding and sponsorship
Study publications
N/A
Data Protection
Email: fa280@leicester.ac.uk
Phone: 0116 258 4312