DOMINO: Diabetes in Pregnancy Optimising Maternal and Infant Outcomes
Background
Pregnancies in women with type 1 diabetes and early-onset type 2 diabetes carry a higher risk of complications for the baby. Even though recent research shows that keeping blood sugar levels under better control can reduce problems like babies being too large, needing intensive care, or having low blood sugar after birth. Outcomes are still not as good as they should be. This highlights the urgent need to better identify which pregnancies are most at risk and find more effective ways to improve the health of both mother and baby.
Study aims
This study aims to improve pregnancy care for people with type 1 diabetes and early-onset type 2 diabetes. For those with type 1 diabetes, we’ll explore how the pancreas is functioning through looking at a protein called C-peptide. For those with early-onset type 2 diabetes, we’ll look at how factors like diet, exercise, glucose control and weight changes affect pregnancy outcomes.
Study summary
This study will align with your regular antenatal clinic appointments at 12,20,28 and 34-36 weeks’ gestation. At these visits we would like to take a few extra blood tests. In addition, we’ll gather data from a continuous glucose monitor and an activity tracker that you’ll wear during the study.
Study progress
Recruiting.
Funding and sponsorship
The University of Leicester is the Sponsor for this study. This research is funded by Diabetes UK. We are conducting the research at University Hospitals of Leicester in conjunction with the Leicester Diabetes Centre.
Study publications
N/A
Data Protection
Research team
Chief investigator: Professor Claire Meek
Trial Manager: Lauren Senior
For more information, please contact: uhl-tr.dominostudy@nhs.net