BariEX
The effect of acute aerobic exercise on the time spent in hypoglycaemia after Roux-en-Y gastric bypass. (The BariEX Study)
Study title
Weight-loss (bariatric) surgery is an effective method which helps people living with severe obesity to achieve and maintain substantial weight loss and live longer. Exercise after bariatric surgery is an important factor which improves fitness, physical function (e.g. strength, endurance and flexibility), and health related quality of life.
Recent research suggests that aerobic exercise after bariatric surgery (in people without type 2 diabetes) increases the bodies’ effectiveness to use the sugar in the blood (insulin sensitivity). Increased insulin sensitivity can cause episodes of low blood glucose levels in individuals’ post-bariatric surgery especially after eating and when undertaking daily lifestyle activities. This can contribute to a reduction in quality of life and cause weight regain.
Current guidelines recommend that after bariatric surgery, individuals should undertake 30 minutes of aerobic exercise. However, there is lack of evidence on the effect of aerobic exercise on blood glucose levels.
Background
To investigate whether a single 30 minute bout of aerobic exercise increases the time spent with low blood sugar levels over the following 24-hours in individuals at least 12 months post bariatric surgery.
Study aims
This is a single centre, randomised, two-period, crossover study with the following experimental sequences:
Sitting and walking at visit two followed by prolonged sitting at visit four.
OR
Prolonged sitting at visit two followed by sitting and walking at visit four
The total study duration is approximately one month per participant. Participants will attend six visits in total. These will be a combination of face-to-face and virtual appointments.
This study will investigate how 30 minute exercise affects blood sugar levels, insulin and hormone levels.
Study summary
Study progress
March 2022 – Open for recruitment
Funder: The Novo Nordisk UK Research Foundation and National Institute for Health Research (NIHR) Leicester BRC.
Sponsor: University of Leicester
Funding and sponsorship
None yet
Study publications
Download the privacy statement here.
Data protection
Chief Investigator: Dr Dimitris Papamargaritis
Principle Investigator: Dr Louisa Herring
Trial Manager: Mamta Joshi
For more information about the BariEx trial, please contact us on the below:
Phone: 0116 258 4023
Email: BariEX_Mailbox@uhl-tr.nhs.uk